Chronic pain: an update on burden, best practices, and new …
WEBChronic pain exerts an enormous personal and economic burden, affecting more than 30% of people worldwide according to some studies. Unlike acute pain, which carries survival value, chronic pain might be best considered to be a disease, with treatment (eg, to be active despite the pain) and psychological (eg, pain acceptance and optimism as goals) …
Interstitial lung diseases - The Lancet
WEBOver 200 interstitial lung diseases, from ultra rare to relatively common, are recognised. Most interstitial lung diseases are characterised by inflammation or fibrosis within the interstitial space, the primary consequence of which is impaired gas exchange, resulting in breathlessness, diminished exercise tolerance, and decreased quality of life. Outcomes …
Growing up in a digital world: benefits and risks - The Lancet
WEBJan 5, 2018 · Digital technologies have profoundly changed childhood and adolescence. The internet and the means to access it, such as tablets and smartphones, along with social media platforms and messaging apps, have become integral to the lives of youth around the world. They have transformed their education and learning, the way they make and …
How to stop stigma: implementing The - The Lancet
WEBNov 23, 2023 · Stigma is a powerful force for social exclusion. In a 2022 survey by the Global Mental Health Peer Network, 80% of more than 400 participants in 45 countries worldwide agreed that “stigma and discrimination can be worse than the impact of the mental health condition itself”.1 In the 2022 Lancet Commission on Ending Stigma and …
Complex post-traumatic stress disorder - The Lancet
WEBComplex post-traumatic stress disorder (complex PTSD) is a severe mental disorder that emerges in response to traumatic life events. Complex PTSD is characterised by three core post-traumatic symptom clusters, along with chronic and pervasive disturbances in emotion regulation, identity, and relationships. Complex PTSD has been adopted as a new …
Azithromycin for mild-to-moderate COVID-19 - The Lancet
WEBSep 9, 2021 · As stated in the introduction of the Article, 1 the antiviral and anti-inflammatory properties of azithromycin are suited to patients with early stage COVID-19. However, patients approaching 14 days since symptom onset might not represent the target study population (ie, those with mild-to-moderate disease), as some patients could be in …
Antiviral effect of high-dose ivermectin in adults with COVID-19: A ...
WEBJun 17, 2021 · 45 participants were recruited (30 to IVM and 15 controls) between May 18 and September 9, 2020. There was no difference in viral load reduction between groups but a significant difference was found in patients with higher median plasma IVM levels (72% IQR 59–77) versus untreated controls (42% IQR 31–73) (p = 0·004).Mean ivermectin …
How an outbreak became a pandemic: a chronological ... - The …
WEBDec 4, 2021 · Understanding the spread of SARS-CoV-2, how and when evidence emerged, and the timing of local, national, regional, and global responses is essential to establish how an outbreak became a pandemic and to prepare for future health threats. With that aim, the Independent Panel for Pandemic Preparedness and Response has …
Understanding the new therapeutic options for mesothelioma
WEBSep 6, 2021 · Since the US Food and Drug Administration (FDA) approved pemetrexed plus cisplatin for first-line treatment of mesothelioma in 2004,1 there has been a dearth of additional treatment options for this disease. Despite substantial effort, no other phase 3 study achieved a positive outcome for another 12 years, until the MAPS trial showed …
Ultra-processed foods and human health: What do we already …
WEBJan 19, 2021 · Western diets are characterized by high intakes of energy-dense products, often with high amounts of sugars and sugary drinks, salt, and saturated fats, and limited amounts of fruit and vegetables, whole grains, and thus dietary fiber and vitamins. Strong scientific concordance linking these dietary factors to chronic diseases has been …