The lifecycle of the Ebola virus in host cells - PMC
WEBAug 8, 2017 · This review describes the biological functions of EBOV proteins and their roles in the lifecycle, summarizes the factors related to EBOV proteins or RNA expression throughout the different phases, and reviews advances with regards to the molecular events and mechanisms of the EBOV lifecycle.
Molecular insights into the Ebola virus life cycle - Nature
WEBMay 23, 2024 · Ebola virus and other orthoebolaviruses cause severe haemorrhagic fevers in humans, with very high case fatality rates. Their non-segmented single-stranded RNA genome encodes only seven...
Structural and Functional Aspects of Ebola Virus Proteins
WEBOct 15, 2021 · Ebola virus (EBOV), member of genus Ebolavirus, family Filoviridae, have a non-segmented, single-stranded RNA that contains seven genes: (a) nucleoprotein (NP), (b) viral protein 35 (VP35), (c) VP40, (d) glycoprotein (GP), (e) …
Molecular mechanisms of Ebola virus pathogenesis: focus on cell …
WEBMay 29, 2015 · The EBOV first attacks macrophages and dendritic immune cells. The innate immune reaction is characterized by a cytokine storm, with secretion of numerous pro-inflammatory cytokines,...
Immunological Perspective for Ebola Virus Infection and Various ...
WEBOct 17, 2020 · 2.1. Cell Targets. EBOV can infect almost any cell, except lymphocytes (reviewed in [23]); however, virus propagation was demonstrated in limited cell types such as fibroblasts, endothelial cells, NK cells, epithelial cells and hepatocytes (reviewed in [24]).
Single-Cell Profiling of Ebola Virus Disease
WEBNov 6, 2020 · Single-cell profiling of circulating immune cells during Ebola virus (EBOV) infection in non-human primates resolves molecular correlates of viral tropism, characterizes replication dynamics within infected cells, and distinguishes expression changes that are mediated by viral infection from those due to cytokine signaling.
Ebola | New England Journal of Medicine
WEBMay 6, 2020 · Disease is caused by direct effects of viral replication and host responses to infection. 18 Viral replication leads to the formation of intracellular inclusion bodies, followed by cell...
Structure of the Ebola virus polymerase complex | Nature
WEBSep 28, 2022 · Structural studies of the Ebola virus polymerase complex provide insights into its function and demonstrate the structural basis of its inhibition by suramin.
Ebola virus disease - World Health Organization (WHO)
WEBApr 20, 2023 · Overview. Ebola virus disease (EVD or Ebola) is a rare but severe illness in humans. It is often fatal. People get infected with Ebola by touching: infected animals when preparing, cooking or eating them. body fluids of an infected person such as saliva, urine, faeces or semen.
How Ebola Virus Infects Cells | New England Journal of Medicine
WEBJun 23, 2005 · Embedded within the host-derived lipid envelope of Ebola virus are glycoprotein spikes that bind to cells and mediate fusion between the viral envelope and the host cell membrane, enabling the...